• STAT+: New CRISPR tools could fix diseases caused by large DNA rearrangements, scientists report

    10 days ago - By STAT

    Ever since the now Nobel-winning discovery of CRISPR genome editing in 2012, scientists have been racing to improve on its DNA-targeting-and-cutting action. A huge step forward came in 2016, with the invention of base editing , and another with prime editing in 2019, both from the Broad Institute lab of David Liu. The advances made it possible to precisely slice open a double-strand of DNA and change the sequence - swap out a nucleotide for another, or add or subtract a few in one go. But when faced with making bigger deletions, anything over 100 base pairs, even these shiny new tools...
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